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Designer Materials for Nucleic Acid Delivery, 635
T.M. Reineke and M.W. Grinstaff, Guest Editors
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Polymeric Controlled Nucleic Acid Delivery, 640
K.W. Leong
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Functional Amphiphiles for Gene Delivery, 647
P. Barthélémy and M. Camplo
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Nanotechnology and DNA Delivery, 654
D. Luo
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Gene Delivery by Immobilization to Cell-Adhesive Substrates, 659
Z. Bengali and L.D. Shea
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Peptide-Enhanced Nucleic Acid Delivery, 663
J.M. Bergen and S.H. Pun
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Abstracts for October 2005 Journal of Materials Research, 618

Letter from the President, 627
The New http://www.mrs.org Improves Member Services, D.J. Eaglesham

Research/Researchers, 628

Science Policy, 633

Advertisers in This Issue, 653

Material Morsels, 668

Calendar, 674

Classified, 676

Posterminaries, 680
Sticky Materials, P. Goodhew

Volume 30, No. 9
September 2005
Masthead

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ON THE COVER: Designer Materials for Nucleic Acid Delivery. (foreground, left) Widefield-fluorescence microscopy images of HeLa cells transfected with polyplexes formed with a rhodamine-labeled poly(glycoamidoamine) delivery vector [see the introductory article, Chart 1 (a)] complexed with fluorescein-labeled plasmid DNA. Top to bottom, the images show intracellular location of the delivery vector; intracellular location of the fluorescein-pDNA; the cellular nucleus, stained for visibility; and an overlay of the first three images, showing the cellular distribution of the polyplexes. (Images courtesy of Katye Fichter, University of Cincinnati.) (foreground, right) Nuclear targeting of peptide-modified quantum dots in NIH 3T3 cells. The quantum dots were surface-modified with poly(ethylene glycol) (PEG) or PEG covalently linked to a nuclear localization sequence (NLS) peptide, then microinjected into cells. (top right) PEGylated quantum dots without the NLS were excluded from the nucleus; (bottom right) quantum dots displaying the NLS were trafficked into the nucleus within 2 h after injection. The NLS peptide has been studied for its ability to enhance nucleic acid delivery to the nucleus. (Images courtesy of Jamie Bergen, University of Washington.) (background) An illustration of a DNA double helix. See the technical theme that begins on p. 635.